妊娠期肝内胆汁淤积症围生儿死亡的高危因素分析

目的研究妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy,ICP）围生儿死亡的高危因素,为临床诊治提供参考。方法回顾性分析我院2001年11月1日~2011年11月1日住院的ICP患者183例,其中死胎病例23例作为实验组,分娩为活胎病例160例作为对照组,实验组和对照组进行单因素非条件和多因素非条件的Logis-tic回归分析。结果单因素分析结果表明ICP患者发病孕周、总胆汁酸、总胆红素、羊水污染和胎儿宫内窘迫改变均与围生儿死亡相关（P〈0.05）,多因素Logistic回归分析表明总胆汁酸、总胆红素、羊水污染和胎儿宫内窘迫改变均具有差异（P〈0.05）。结论围生儿死亡高危因素为总胆汁酸、总胆红素、羊水污染和胎儿宫内窘迫。

Factor analysis of fetal death in intrahepatic cholestasis of pregnaney

Objective To study risk factors for perinatal death of intrahepatic cholestasis of pregnaney(ICP),provide reference for clinical diagnosis and treatment.Methods Retrospective analysis on 183 patients with ICP from November 2001 to November 2011 in our hospital,Stillbirth 23 cases as experimental group,160 patients with live birth as control group,the experimental group and control group were the single factor and many factors of Logistic regression analysis.Results Single factor analysis results showed that patients with weeks of ICP,the total bile acid,total bilirubin,amniotic fluid pollution and fetal distress were related to perinatal death,the difference was statistically significant(P < 0.05).Many factors Logistic regression analysis showed that the total bile acid,total bilirubin,amniotic fluid pollution and fetal distress were related to perinatal death,the difference was statistically significant(P < 0.05).Conclusion Risk factors of perinatal death are the total bile acid,total bilirubin,amniotic fluid pollution and fetal distress palace.