TNRC9基因多态性与乳腺癌的相关性研究

目的探讨中国籍汉族人群的TNRC9基因多态性与乳腺癌的相关性。方法选取325例乳腺癌患者为研究组,另外选取325例健康人群为对照组,提取两组患者的基因组DNA,采用聚合酶链反应-连接酶检测反应法检测TNRC9 rs12443621基因的多态性,分析其与乳腺癌易感因素和临床病理的相关性。结果 TNRC9 rs12443621 AA、AG和GG基因在研究组与对照组分别占18.1%、46.5%、35.4%和18.7%、48.3%、33.0%。孕激素、雌激素状态和淋巴结转移情况与TNRC9 rs12443621基因型无相关性（χ^2值分别为0.081、0.335、0.331,均P〉0.05）。结论中国汉族人群中TNRC9 rs12443621基因与乳腺癌的易感因素可能无关,TNRC9 rs12443621基因不能单独作为乳腺癌的筛查的标志物。

Research of the correlation of TNRC9 genetic polymorphism and breast cancer

Objective To study the correlation of genetic polymorphism TNRC9 and breast cancer in Chinese han nationality people.Methods The patients of 325 cases with breast cancer were selected as the study group,325 healthy cases were selected as control group;extracted the genomic DNA of two groups;detected the TNRC9 rs12443621 reaction of the gene polymorphism by the polymerase chain reaction-links enzyme detection method;analyzed the correlation between breast cancer risk factor and clinical pathologic.Results TNRC9 rs12443621 AA,AG and GG gene in the study group and control group were 18.1%,46.5%,35.4% and 18.7%,48.3%,33.0%.There were no correlation between Progesterone,estrogen level,lymph node metastasis and TNRC9 rs12443621 genotype(χ2 value respectively was 0.081、0.335、0.331,all P > 0.05).Conclusion TNRC9 rs12443621 genes of Chinese han nationality people may be irrelevant with the risk factor of breast cancer,TNRC9 rs12443621 gene can’t be the markers screening for breast cancer separately.