| 单采血小板保存期间部分参数的改变及其意义 |
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| 引用本文： | 曹惠,卓海龙,徐丽娟,王海平,王全立.单采血小板保存期间部分参数的改变及其意义[J].中国医药导报,2012,9(13):86-87. |
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| 作者姓名： | 曹惠 卓海龙 徐丽娟 王海平 王全立 |
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| 作者单位： | 1. 解放军总医院输血科,北京,100853;军事医学科学院附属医院输血科,北京,100039
2. 军事医学科学院附属医院输血科,北京,100039 |
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| 摘 要： | 目的观察分析单采血小板在保存期间各项指标的改变,探讨储存损伤对血小板的影响。方法检测单采血小板22℃震荡保存1、3、5、7 d的MPV、PDW、PLT、活化率和血浆中S1P浓度。结果随保存时间的延长,单采血小板保存期间MPV和PDW升高,PLT下降,活化率增高,血浆中S1P浓度上升。结论血小板在保存期间发生一定程度的活化,甚至凋亡,说明储存损伤影响了血小板质量,并有可能影响临床输注效果。
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| 关 键 词： | 机采血小板 储存损伤 活化 |
Changes of parameters of apheresis platelets during storage and its significance |
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| CAO Hui
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ZHUO Hailong
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XU Lijuan
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WANG Haiping
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WANG Quanli.Changes of parameters of apheresis platelets during storage and its significance[J].China Medical Herald,2012,9(13):86-87. |
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| Authors: | CAO Hui ZHUO Hailong XU Lijuan WANG Haiping WANG Quanli |
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| Institution: | 1.Department of Blood Transfusion,the General Hospital of People’s Liberation Army,Beijing 100853,China;2.Department of Blood Transfusion,the Affiliated Hospital of Academy of Military Medical Sciences,Beijing 100039,China |
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| Abstract: | Objective To observe and analyze the changes of indicators of apheresis platelets during storage and to explore the impact of shake storage damage on platelet.Methods MPV,PDW,PLT,activation rate and plasma S1P concentration of apheresis platelet 1,3,5 and 7 days after shake storage at 22 °C were detected.Results With the extension of storage time,MPV and PDW increased,PLT gradually decreased,activation rate and plasma S1P concentration increased.Conclusion Platelet is activated to a certain extent,or even resulted in apoptosis during storage,which indicates that storage affects the quality of the platelets and thus may affect clinical transfusion effect. |
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| Keywords: | Platelets Storage damage Activation |
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