早期肠内营养联合益生菌治疗重症胰腺炎

目的探讨早期肠内营养（EN）联合益生菌在急性重症胰腺炎（SAP）治疗中的应用价值。方法将49例SAP患者随机分两组,对照组予常规治疗,EN组在常规治疗基础上通过鼻空肠管给予早期肠内营养并联用益生菌。观察两组患者入院时及入院后2周的APACHEⅡ评分、Balthazar CT积分,对两组的感染率、并发症及死亡率、住院时间、住院总费用对比。结果 EN组治疗前后APACHEⅡ评分差值明显高于对照组（P〈0.05）,而两组Balthazar CT评分及差值均无统计学意义（均P〉0.05）。EN组在继发感染、并发症、住院时间和费用上均少于对照组（均P〈0.05）;在死亡率方面,两组差异无统计学意义（P〉0.05）。结论在SAP治疗中应用鼻空肠管进行早期肠内营养联合益生菌,可以改善SAP患者的营养状况,加快症状恢复,减少并发症,缩短病程,减少医疗费用。

Treatment of severe acute pancreatitis with early enteral nutrition and probiotics

Objective To evaluate the efficacy of early enteral nutrition and probiotics on severe acute pancreatitis(SAP).Methods 49 patients with SAP were randomly divided into the control group and enteral nutrition(EN) groups.The control group was given conventional therapy,EN group were treated at the same time through the nasojejunal tube early enteral nutrition in parallel with probiotics.The APACHEⅡ score and Balthazar CT score on admission and two weeks were observed.Infection rate,complications and mortality,cost of hospitalization and length of stay were measured.Results APACHEⅡ scores before and after treatment difference in the EN group was significantly higher than the control group(P <0.05),Balthazar CT score and the difference between the two groups were not statistically significant(P > 0.05).EN group in the secondary infection,complications,hospital stay and cost less than the control group,the difference was statistically significant(P <0.05);In terms of mortality,no significant difference(P > 0.05).Conclusion Treatment of SAP with early enteral nutrition and probiotics can improve nutrition,speed up symptom recovery,reduce complications,shorten length of stay and reduce medical costs.