Neuroticism and the brain: A quantitative meta-analysis of neuroimaging studies investigating emotion processing |
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| Authors: | Michelle N. Servaas,Jorien van der Velde,Sergi G. Costafreda,Paul Horton,Johan Ormel,Harrië tte Riese,André Aleman |
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| Affiliation: | 1. Neuroimaging Center, Department of Neuroscience, University of Groningen/University Medical Center Groningen, Antonius Deusinglaan 2, 9713 AW, Groningen, the Netherlands;2. Interdisciplinary Center for Psychopathology and Emotion Regulation, University of Groningen/University Medical Center Groningen, Hanzeplein 1–Entrance 24, 9713 GZ, Groningen, the Netherlands;3. Department of Epidemiology, University of Groningen/University Medical Center Groningen, Hanzeplein 1–Entrance 24, 9713 GZ, Groningen, the Netherlands;4. Institute of Psychiatry, Department of Old Age Psychiatry, King''s College London, Box PO 070, De Crespigny Park, SE5 8AF London, United Kingdom;5. Department of Psychology, University of Groningen, Grote Kruisstraat 2, 9712 TS, Groningen, the Netherlands |
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| Abstract: | Neuroticism is a robust personality trait that constitutes a risk factor for mood disorders. Neuroimaging findings related to neuroticism have been inconsistent across studies and hardly integrated in order to construct a model of the underlying neural correlates of neuroticism. The aim of the current meta-analysis was to provide a quantitative summary of the literature, using a parametric coordinate-based meta-analysis (PCM) approach. Data were pooled for emotion processing tasks investigating the contrasts (negative > neutral) and (positive > neutral) to identify brain regions that are consistently associated with neuroticism across studies. Significant negative and positive correlations with neuroticism were found only for the contrast (negative > neutral) after multiple comparisons correction. Differences in brain activation were found to be associated with neuroticism during fear learning, anticipation of aversive stimuli and the processing and regulation of emotion. The relationship between neuroticism and these three psychological processes and their corresponding neural correlates is discussed. Furthermore, the meta-analytic findings are incorporated into a general model of emotion processing in neuroticism. |
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| Keywords: | Anterior cingulate cortex Anticipation of aversive stimuli Emotion processing and regulation Fear learning Frontal and cingulate regions Functional magnetic resonance imaging (fMRI) Hippocampus Negative stimuli Parametric coordinate-based meta-analysis (PCM) Posterior cingulate cortex |
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