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Psychosis in a cocaine-dependent patient with ADHD during treatment with methylphenidate
Authors:  loï  se Delavenne,Frederico Duarte Garcia,Jé    me Lacoste,Samuele Cortese,Aimé   Charles-Nicolas,Nicolas Ballon
Affiliation:1. Department of Psychiatry, Universidade Federal de Minas Gerais (UFMG), Brazil;2. INSERM Unity U 1073, Rouen University Hospital and Biomedical Research Institute, Rouen University, France;3. Department of Psychiatry and Addictology & EA 4537, Fort-de-France University Hospital, Martinique, French West Indies;4. INSERM Unity U 930, François-Rabelais University, Tours, France;5. Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY, USA;6. Child Psychiatry Centre, Clinique Psychiatrique Universitaire and Equipe de Liaison et de Soins en Addictologie, University Hospital, Tours, France
Abstract:

Objective

The objective was to report a case of experienced psychosis during the treatment with methylphenidate (MPH) in a cocaine-dependent adult treated for attention-deficit/hyperactivity disorder (ADHD) with comorbid cocaine dependence.

Conclusion

ADHD is a frequent comorbidity in substance use disorder (SUD) patients. MPH may be effective in treating ADHD symptoms in SUD patients, thus preventing possible adverse outcomes. Cocaine-induced psychosis may be a risk factor for development of psychosis in the presence of a concurrent treatment with MPH.
Keywords:Psychosis-induced   ADHD   Cocaine   Substance use disorder   Methylphenidate   Adverse effect   Dopamine
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