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Acute monocytic leukemia with (8;22)(p11;q13) translocation Involvement of 8p11 as in classical t(8;16)(p11;p13) |
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| Authors: | J. L. Lai M. Zandecki P. Fenaux C. Preudhomme T. Facon M. Deminatti |
| Affiliation: | a Service de Cytogénétique, Faculté de Médecine Lille, France b Laboratoire d'Hématologie, Hôpital Calmette Lille, France c Service des Maladies du Sang, Hôpital Huriez Lille, France |
| Abstract: | A new case of acute monocytic leukemia observed in a 73-year-old male (ANLLM5) with an unusual t(8;22)(p11;q13) is reported. The blasts did not demonstrate erythrophagocytosis, but the presence of both naphtol-ASD-chloro-acetate esterase and butyrate esterase activities was similar to that seen in cases with t(8;16)(p11;p13). Involvement of the 8p11 region in ANLLM4 and M5 is discussed, being the third most frequent rearrangement in acute leukemia with monocytic components seen at our Center. |
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