化疗栓塞方法和肝细胞癌组织反应

目的评价肝细胞癌肿瘤包膜、淋巴细胞浸润、纤维化、肝硬化等与经动脉化疗栓塞（TACE）方法的关系。方法观察117例手术切除的肝细胞癌肿瘤包膜、淋巴细胞浸润、纤维化、肝硬化程度，其中单纯手术58例，4种TACE后Ⅱ期手术切除59例。结果TACE组较单纯手术组，肝细胞癌包膜更厚、更完整，淋巴细胞浸润多，纤维化多（Ρ＜0.01）；包膜形成、纤维化与TACE方法、次数及手术间期密切相关（Ρ＜0.05），淋巴细胞浸润与TACE方法、次数密切相关（Ρ＜0.05），与手术间期关系不大（Ρ＞0.05）。肝硬化与治疗方法关系不大（Ρ＞0.05），但与治疗次数相关（Ρ＜0.05）。结论多次、多材料联合栓塞TACE较单次、单材料栓塞、单纯化疗更易引起肝细胞癌包膜形成、淋巴细胞浸润、纤维化，超选择性插管可避免TACE对正常肝的损害。

he Relationship Between the Tumor Tissue Reaction and Transcatheter Arterial Chemoembolization Methods for Hepatocellular Carcinoma

Objective　To evaluate the relationship between the tumor encapsulation,lymphocytic infiltration,fibroplasia and cirrhosis and transcatheter arterial chemoembolization(TACE)methods for hepatocellular carcinoma(HCC).Methods　Histopathological changes were studied in 59 cases of HCCs treated with four kinds of TACE and 58 cases of HCCs treated with surgical resection alone.Results　In TACE group the encapsulation,lymphocytic infiltration,fibroplasia was more severe and extensive than that in group of surgical resection alone(Ρ＜0.01）.The TACE method and treatment time had effect on encapsulation and fibroplasia of tumor,but treatment interval was no effect.The rate of cirrhosis among TACE method had no significantly difference（Ρ＞0.05）,had relation to TACE time（Ρ＜0.05）.Conclusion　The changes in the encapsulation,lymphocytic infiltration,fibroplasia are more easily find by polytimes,multimaterial chemoembolization than that by one time single material chemoembolization and chemotherapy alone.The superselective cathetering can avoid the damage of normal liver.