Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST |
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Authors: | Nishino Mizuki Jagannathan Jyothi P Krajewski Katherine M O'Regan Kevin Hatabu Hiroto Shapiro Geoffrey Ramaiya Nikhil H |
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Institution: | Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Mizuki_Nishino@dfci.harvard.edu |
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Abstract: | OBJECTIVE: The purpose of this article is to review cancer- and therapy-specific tumor response assessment criteria used in clinical trials and in practice, with illustrative case examples, and to discuss future directions toward "personalized" tumor response assessment. CONCLUSION: Although Response Evaluation Criteria in Solid Tumors will remain as the primary generalized criteria for response assessment, newer cancer- and therapy-specific criteria will play an important role in providing state-of-the-art response assessment of tumor following molecular targeted therapy and will contribute to personalized cancer care in the era of molecular medicine. |
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