| RP-HPLC法同时测定保心宁胶囊中三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的含量 |
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| 引用本文： | 张婷,魏尊喜.RP-HPLC法同时测定保心宁胶囊中三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的含量[J].安徽医药,2010,14(5):531-533. |
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| 作者姓名： | 张婷 魏尊喜 |
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| 作者单位： | 安徽省淮北市食品药品检验所,安徽,淮北,235000;安徽省淮北市食品药品检验所,安徽,淮北,235000 |
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| 摘 要： | 目的采用HPLC梯度洗脱法同时测定保心宁胶囊中三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1含量。方法采用ODS-C18柱,流动相为乙腈（A）-水（B）（0~12 min,A：19%;12~60 min,19%~36%;60~70 min,36%）;检测波长为203 nm;流速：1.0 ml.min-1。结果三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的线性范围分别为0.764~6.365μg（r=0.9999）、0.633~5.275μg（r=0.9999）、0.699~5.825μg（r=0.9999）,平均加样回收率分别为99.88%（RSD=0.55%）、99.97%（RSD=0.23%）、100.04%（RSD=0.15%）。结论该方法易行、准确可靠,可用于保心宁胶囊的质量控制。
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| 关 键 词： | 保心宁胶囊 三七皂苷R1 人参皂苷Rg1 人参皂苷Rb1 HPLC |
Simultaneous determination of notoginsenoside R1 and ginsenoside Rg1,Rb1 in Baoxinning Capsules by HPLC |
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| ZHANG Ting,WEI Zun-xi.Simultaneous determination of notoginsenoside R1 and ginsenoside Rg1,Rb1 in Baoxinning Capsules by HPLC[J].Anhui Medical and Pharmaceutical Journal,2010,14(5):531-533. |
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| Authors: | ZHANG Ting WEI Zun-xi |
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| Institution: | ZHANG Ting,WEI Zun-xi(Huaibei Institute for Food and Drug Control,Huaibei 235000,China) |
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| Abstract: | Aim To determine notoginsenoside Rl and ginsenoside Rg1,Rb1 in Baoxinning Capsules by HPLC.Methods The ODS-C18 column was used.A mobile phase consisted of acetonitrile(A)-water(B)(0~12 min,A:19%;12~60 min,19%~36%;60~70 min,36%) gradient elution.The detection wavelength was at 203 nm.The flow rate was 1.0 ml·min-1.Results The linear ranges of notoginsenoside R1 and ginsenoside Rg1,Rb1 were 0.764～6.365 μg(r=0.9999)、0.633～5.275 μg(r=0.9999) and 0.699～5.825 μg(r=0.9999),respectively.The average recoveries were 99.88%(RSD=0.55%),99.97%(RSD=0.23%),and 100.04%(RSD=0.15%),respectively.Conclusion The method is simple,accurate and can be used for quality control of baoxinning capsules. |
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| Keywords: | HPLC |
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