597例非淋菌性尿道炎患者支原体感染情况与耐药性分析

目的：分析我院皮肤科2007年1月～2009年12月非淋菌性尿道炎（NGU）患者支原体感染及耐药性变迁情况,为临床提供最新的流行病学资料及用药指导。方法：应用板条培养药敏试剂法对解脲支原体（Uu）和人型支原体（Mh）进行检测和其对11种抗菌药物的药敏试验结果分析。结果：3年共检测临床拟诊为NGU的患者1557例,支原体感染总阳性例数597例,阳性率为38.34%。其中解脲支原体（Ureaplasma urealyticum,Uu）、人型支原体（My-coplasmahominis,Mh）、混合型（Mh＋Uu）检出率分别为78.39%、3.69%、17.92%。女性阳性率为51.71%,男性阳性率为28.96%,女性感染率显著高于男性（χ^2=82.609,P〈0.01）。随年份增加支原体阳性率有逐年增高的趋势,但各年度间差异无统计学意义（P〉0.05）。耐药检测结果表明,支原体对交沙霉素、美满霉素、强力霉素敏感率高（分别为99.16%,98.32%,97.65%）,对环丙沙星的敏感率最低（14.07%）。结论：非淋菌性尿道炎支原体感染主要以Uu发病率最高,且在益阳地区女性检出率高于男性,临床对支原体感染治疗应根据药敏结果合理使用抗生素,以减少耐药菌株产生。

Infection status and drug susceptilibity analysis of Mycoplasma strains in 597 patients with non-gonoeeoeal urethritis

Objective：To analyze Mycoplasma infection in non-gonoeeoeal urethritis（NGU）and the changes in drug resistance from January 2007 to December 2009,to provide the data of epidemiology and instruct rational application of an tibiotics.Methods：Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） were detected with lath culture sensitivity reagent method and drug susceptibility test results were analyzed with 11 kinds of antimicrobial agents.Results：In 1 557 NGU patients,the total positive patients drug resistance by Mycoplasma was 597,the positive rate of Mycoplasma was 38.34%,and the positive rate of Ureaplasma urealyticum（Uu）,Mycoplasma homonis（Mh）,Uu and Mh were 78.39%,3.69%,17.92%.The positive rate in female and male were 51.71% and 28.96%,respectively.The infection rate of female was obviously higher than that of male（χ^2=82.609,P〈0.01）.The postive rate heighten as well as the increased year,but there was no obviously difference in each year（P〈0.05）.The susceptibility test indicated that the drug resistant rate of Mycoplasmas to josamycin,deoxycyline and minoccyline was high（99.16%,98.32%,97.65%）.The drug resistant rate to ciprofloxacin was the lowest（14.07%）.Conclusion：Uu is the main pathogens of NGU with great changes in drug resistance and testing rate of female was higher than that of the male.Clinicians should focus on the susceptibility test and use an tibiotics rationally so as to avoidance the product of the resistance strains.