| 抑肽酶对大鼠实验性脑出血后AQP4mRNA表达及脑水肿的作用 |
| |
| 引用本文： | 田力,申明惠,王佳贺,张萌,张威,高岩,滕伟禹,. 抑肽酶对大鼠实验性脑出血后AQP4mRNA表达及脑水肿的作用[J]. 中国医学工程, 2008, 0(3) |
| |
| 作者姓名： | 田力 申明惠 王佳贺 张萌 张威 高岩 滕伟禹 |
| |
| 作者单位： | 中国医科大学附属盛京医院老年病科;中国医科大学附属盛京医院神经内科;中国医科大学附属第一医院神经内科; |
| |
| 摘 要： | 目的研究脑出血后的脑水肿形成与水孔蛋白-4(AQP4) mRNA表达的关系,以及抑肽酶的干预作用。方法采用自体动脉血注入法制作大鼠脑出血模型,RT-PCR法检测AQP4 mRNA表达,并观察给予抑肽酶处置后脑水肿(脑含水量)的变化。结果与对照组相比,脑出血组和抑肽酶组均从脑出血后6h开始出现脑水肿(P<0.05),3d时达到高峰(P<0.05),分别上升到(82.13±0.36)和(79.48±0.46),且抑肽酶组脑水肿程度低于脑出血组(P<0.05);AQP4 mRNA表达同样在3d时达到高峰(P<0.05),分别为(1.34±0.14)和(1.03±0.05)。脑水肿程度与AQP4 mRNA表达的变化呈显著正相关(r=0.815,P<0.01)。结论脑出血后AQP4 mRNA表达明显增加,提示AQP4参与了脑水肿的发生发展过程,而抑肽酶能够抑制脑水肿的形成。
|
| 关 键 词： | 脑出血 脑水肿 水孔蛋白-4 抑肽酶 |
Effect of aprotinin on AQP4 mRNA expression and cerebral edema after experimental cerebral hemorrhage in rats |
| |
| TIAN Li,SHEN Ming-Hui,WANG Jia-he,ZHANG Meng,ZHANG Wei,GAO Yan,TENG Wei-Yu. Effect of aprotinin on AQP4 mRNA expression and cerebral edema after experimental cerebral hemorrhage in rats[J]. China Medical Engineering, 2008, 0(3) |
| |
| Authors: | TIAN Li SHEN Ming-Hui WANG Jia-he ZHANG Meng ZHANG Wei GAO Yan TENG Wei-Yu |
| |
| Affiliation: | TIAN Li1,SHEN Ming-Hui1,WANG Jia-he1,ZHANG Meng1,ZHANG Wei2,GAO Yan2,TENG Wei-Yu3(1.Ward of Cadre,2.Department of Neurology,the Affiliated Shengjing Hospital,China Medical University,Shenyang,Liaoning 110003,P.R.China,3.Department of Neurology,the First Affiliated Clinical Hospital,Liaoning 110001,P.R.China) |
| |
| Abstract: | 【Objective】Study the relationship between the cerebral edema after cerebral hemorrhage and AQP4 mRNA expression,and the interferent effect of aprotini.【Methods】The ICH models were established by stereotaxic injecting of auto-anticoagulated artery blood into the caudate nucleus,detected AQP4 mRNA expression by RT-PCR,and the change of cerebral edema(cerebral water contents) after giving aprotinin.【Result】Compared with the control group,cerebral edema appeared in ICH group and aprotini group 6 hours after cer... |
| |
| Keywords: | ICH brain edema aprotinin |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国医学工程》浏览原始摘要信息 |
|
点击此处可从《中国医学工程》下载全文 |
|
