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| 血小板糖蛋白HPA-1和HPA-2基因多态性与脑血栓形成的相关性研究 | |
| 引用本文： | 张涌,王荫华,崔才三,李现亮,黄萍,汪运山.血小板糖蛋白HPA-1和HPA-2基因多态性与脑血栓形成的相关性研究[J].中国神经免疫学和神经病学杂志,2006,13(3):140-143. |
| 作者姓名： | 张涌 王荫华 崔才三 李现亮 黄萍 汪运山 |
| 作者单位： | 1. 北京大学第一医院神经内科,北京,100034;济南市中心医院神经内科,山东,济南,250013 2. 北京大学第一医院神经内科,北京,100034 3. 山东大学齐鲁医院神经内科,山东,济南,250012 4. 济南市中心医院医学检验中心,山东,济南,250013 |
| 基金项目： | 山东省济南市留学创业计划资助项目 |
| 摘 要： | 目的探讨血小板糖蛋白人类血小板同种异型抗原系统-1(HPA-1)和HPA-2基因多态性与脑血栓形成的相关性。方法收集脑血栓形成患者108例及无神经系统疾病的日常查体者166例,应用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP)检测HPA-1、HPA-2多态性在两组中的分布频率。结果血小板糖蛋白基因HPA-1、HPA-2多态性在脑血栓组和对照组中的基因型频率和等位基因频率分布差异无统计学意义。结论血小板糖蛋白基因HPA-1、HPA-2多态性与脑血栓形成无相关性。 |
| 关 键 词： | 脑血栓形成 血小板糖蛋白 多态性 相关性研究 |
| 文章编号： | 1006-2963（2006）03-0140-04 |
| 收稿时间： | 2005-06-03 |
| 修稿时间： | 2005-11-30 |
Association Study of Platelet Glycoprotein HPA-1 and HPA-2 Polymorphism with Cerebral Vascular Thrombosis |
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| ZHANG Yong,WANG Yin-hua,CUI Cai-san,LI Xian-liang,HUANG Ping,WANG Yun-shan.Association Study of Platelet Glycoprotein HPA-1 and HPA-2 Polymorphism with Cerebral Vascular Thrombosis[J].Chinese Journal of Neuroimmunology and Neurology,2006,13(3):140-143. | |
| Authors: | ZHANG Yong WANG Yin-hua CUI Cai-san LI Xian-liang HUANG Ping WANG Yun-shan |
| Institution: | 1. Department of Neurology, First Hospital of Peking University, Beijing 100034, 2. Department of Neurology, Jinan Central Hospital, Shandong Jinan 250013, 3. Department of Neurology, Qilu Hospital of Shandong University, Shandong Jinan 250012, 4. Medical Diagnostic Laboratory Center, Jinan Central Hospital, Shandong Jinan 250013, China |
| Abstract: | Objective To evaluate association between platelet glycoprotein HPA-1,HPA-2 polymorphisms and cerebral vascular thrombosis.Methods 108 patients of cerebral vascular thrombosis and 166 age matched controls were included in the cohort.HPA-1 and HPA-2 polymorphisms were detected by polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP).Results There were no significant differences in HPA-1 and HPA-2 genotype frequencies and allele frequencies between cerebral vascular thrombosis patients and controls.Conclusions Platelet glycoprotein HPA-1 and HPA-2 polymorphisms are not associated with cerebral vascular thrombosis in our cohort. |
| Keywords: | cerebral vascular thrombosis glycoprotein polymorphism association study |
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