In Vitro Activity of the New Echinocandin Antifungal, MK-0991, against Common and Uncommon Clinical Isolates of Candida Species |
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| Authors: | F Barchiesi A M Schimizzi A W Fothergill G Scalise M G Rinaldi |
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| Institution: | (1) Istituto di Malattie Infettive e Medicina Pubblica, Università degli Studi di Ancona, Ospedale Umberto I, Largo Cappelli 1, I-60121, Ancona, Italy, IT;(2) Fungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7750, USA, US |
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| Abstract: | A broth macrodilution method, performed as recommended by the National Committee for Clinical Laboratory Standards, was used
for comparative testing of the new echinocandin antifungal agent MK-0991 and fluconazole against 50 yeast isolates belonging
to 12 species of Candida. MK-0991 was shown to be highly effective against both fluconazole-susceptible and -resistant Candida spp., yielding minimum inhibitory concentrations ranging from ≤0.19 to 0.78 μg/ml. Fungicidal activity was exerted at ≤1.5 μg/ml
for 73% of the isolates tested. This study suggests that MK-0991 has significant potential for clinical development. |
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