Synthesis and CNS- activity of cis-pyrano[2,3-b]-[1,4]dioxane derivatives |
| |
| Authors: | F Eiden B Wünsch J Schünemann |
| |
| Institution: | Institut für Pharmazie und Lebensmittelchemie, Universit?t München. |
| |
| Abstract: | The alcohols 2, the amines 5, 7 and 10, the indole- and quinoline-derivatives 13 and 14, the enamines 3 and 4 and the silylenolethers 17 and 18 were prepared starting with the title compound 1. The 1-(7-phenyl-7-pyranodioxinyl)-piperidines 10-cis and 10-trans show striking CNS-activity. The transisomer is about twice as active as the cis-isomer. |
| |
| Keywords: | |
|
|
