Cadherin cell adhesion molecules in vertebrate neural development |
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| Institution: | 1. Genome Regulation Laboratory, Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;2. Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;3. Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;1. Department of Animal & Poultry Sciences, Virginia Tech, Blacksburg, VA, USA;2. Department of Animal Sciences, Texas A&M University, College Station, TX, USA;3. Department of Dairy Science, Virginia Tech, Blacksburg, VA, USA;1. Department of Psychology, The University of Sheffield, Sheffield, United Kingdom;2. Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada;3. The Archie and Irene Verspeeten Clinical Genome Centre, London Health Sciences Foundation, London Health Sciences Centre, London, Ontario, Canada;4. Biosciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom;5. Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom;6. Department of Clinical Genetics, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom;7. Peninsula Clinical Genetics Service, RD&E Heavitree Hospital, Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom;8. Department of Pediatrics and Children’s Research Institute, Medical College of Wisconsin, Children’s Wisconsin, Milwaukee, WI;9. Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom;10. Manchester Centre for Genomic Medicine, Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom;11. Service of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland;12. Ruhr-Universitat Bochum, Abteilung für Humangenetik, Bochum, Germany;13. Clinical Genetics, Addenbrooke’s Treatment Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom;14. Clinical Genetics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom;15. West Midlands Regional Clinical Genetics Centre and Department of Clinical Genetics, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, United Kingdom;16. Ambulanzzentrum UKSH, Institut für Humangenetik, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany;17. Department of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India;18. Medical Genetics Laboratory, Bambino Gesu Children’s Hospital, Rome, Italy;19. Paediatric Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy;20. Angers University Hospital Center, Angers, France;21. Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;22. Department of Human Genetics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;23. EA7364 RADEME, Institute of Medical Genetics, Lille University Hospital, Lille University, Lille, France;24. Faculty of Nutritional Science, Sagami Women''s University, Sagamihara, Japan;25. Department of Medical Genetics, Osaka Women’s and Children’s Hospital, Osaka, Japan;26. Department of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan;27. Laboratory for Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN, Tokyo, Japan;28. Department of Orthopedic Surgery, Keio University School of Medicine, Keio University, Tokyo, Japan;29. Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium;30. Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium;31. Centrum voor Medische Genetica - UZ Gent, Ghent University Hospital, Gent, Belgium;32. Department of Clinical Genetics Service, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom;33. Department of Human Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;34. Department of Neuroscience, The Medical School, The University of Sheffield, Sheffield, United Kingdom;35. Department of Clinical Genetics, Sheffield Children’s Hospital NHS Foundation Trust, Sheffield, United Kingdom |
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| Abstract: | Cellular interactions play a crucial role in the development of the vertebrate nervous system. The molecular analysis of cell adhesion has revealed a family of cell adhesion molecules, the cadherins, that mediate homophilic cell-cell interactions in a calcium-dependent manner. Some of the molecular mechanisms underlying cadherin-mediated cell adhesion have been determined. Recently, several new cadherins were identified in the vertebrate nervous system. The expression patterns of the neural cadherins and initial functional studies suggest that these molecules may play a role in various aspects of neural development. The multiplicity of cadherin subclasses on neural cells and the modulation of their function through associated molecules may specify the multiple adhesive interactions of neural cells during embryonic development. |
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