Absorption of thyrotropin-releasing hormone (TRH) and a TRH prodrug in a human intestinal cell line (Caco-2) |
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| Affiliation: | 2. University of Arizona, Cancer Center, University of Arizona, Tucson, AZ, USA;3. Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA |
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| Abstract: | The transepithelial transport of TRH and its prodrug (N-octyloxycarbonyl) derivative was studied using the human colorectal carcinoma cell line Caco-2. No intact TRH prodrug was transported across the cells. Instead, TRH released from the prodrug was absorbed at rates comparable to those of labelled and unlabelled TRH. No metabolites of TRH could be detected. It can be concluded that the increased lipophilicity of the TRH prodrug is without effect on its transport characteristics. |
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