Chromatin reorganization during senescence of proliferating cells |
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| Affiliation: | 1. Department of Chemistry, Kahramanmaras Sutcu Imam University, Kahramanmaras 46050, Turkey;2. Necmettin Erbakan University, Seydisehir Vocational School, Konya, Turkey;3. School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland;4. Animal Science Genetics Unit, Faculty of Agriculture, Kahramanmaraş Sütçü İmam University, Kahramanmaraş 46050, Turkey;1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea;2. Department of Ophthalmology, Seoul National University Boramae Medical Center, Seoul, Korea;3. Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea;4. Department of Biostatistics, Seoul National University Boramae Medical Center, Seoul, Korea;1. Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland;2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;3. Department of Ophthalmology, University of Colorado Denver—Anschutz Medical Campus, Aurora, Colorado;1. Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy;2. Department of Neuroscience, Psychology, Drug Research and Child Health (NeuroFarBa), Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy;1. Department of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India;2. Department of Physics, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India;3. Department of Chemistry, University of Washington, Seattle, WA 98195, USA;4. Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India |
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| Abstract: | It was previously proposed (Macieira-Coelho, 1979) that aging of proliferating cells is the result of genome reorganization taking place during the division cycle. This hypothesis was investigated and a reorganization could indeed be ascertained in the different hierarchical orders of DNA structure; a correlation was found between changes in chromatin organization and the impairment of cell cycle-related events. Indeed, like the latter, the reorganization of chromatin structure is characterized by a succession of subtle changes through the cell population life span, and a final short stage with abrupt events. The final events seem to concern mainly the organization of heterochromatin.The reorganization in the genome is accompanied by structural changes in the cellular scaffold and an evolution of cell morphology.The remodeling occurring in the cell through serial divisions seems to take place in such a way as to decrease the probability of further reorganizations, tending to a limit. The decline of the proliferative activity seems to be the result of the tendency to reach this limit. |
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