An application of the microdialysis system to the pharmacokinetic study on striatal distribution of L-DOPA with or without carbidopa in rats |
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| Institution: | 1. Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, USA;2. Adult & Gerontological Health Co-Operative, School of Nursing, University of Minnesota, Minneapolis, MN, USA;3. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA |
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| Abstract: | The effect of coadministration of carbidopa on the contents of L-DOPA and its active metabolite, dopamine, in the rat striatum after the intraperitoneal administration of L-DOPA was investigated by the use of the microdialysis system, employing a statistical moment analysis. It was demonstrated that the contents of L-DOPA and dopamine in the striatum were significantly increased by 7.8 and 3.3 times when carbidopa was coadministered, respectively. From the present study, the microdialysis system is found to be a suitable technique to assess the distribution of drugs in the specific brain region in in vivo state. |
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