Dysregulation of the hypothalamo-pituitary-adrenal axis and duration of diabetes |
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| Affiliation: | 1. National Eye Institute, Bethesda, MD USA;2. the National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD USA;1. University of Silesia in Katowice, Department of Medical Physics, A. Chełkowski Institute of Physics, The Silesian Centre for Education and Interdisciplinary Research, ul. 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland;2. NU-MED Cancer Diagnosis and Treatment Centre Katowice, ul. Ceglana 35, 40-514 Katowice, Poland;3. The Jerzy Kukuczka Academy of Physical Education in Katowice, Department of Physiological and Medical Sciences, Department of Biochemistry, ul. Mikołowska 72a, 40-065 Katowice, Poland;1. Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands;2. Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands;3. Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands;4. Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany;1. Department of Health Sciences, Division of Dermatology, University of Florence, Italy;2. St John’s Institute of Dermatology, GSTT NHS Foundation Trust, London, United Kingdom;3. Department of Biology, Research Unit of Histology and Embriology, University of Florence, Italy;1. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA;2. Barbara & Donald Jonas Stem Cell & Regenerative Medicine Laboratory, and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Pathology & Cell Biology, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA;3. Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, New York, USA;1. Ophthalmic Consultants of Boston, Harvard Medical School, Boston, Massachusetts;2. Ophthalmic Mutual Insurance Company, San Francisco, California;3. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts |
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| Abstract: | We compared insulin-dependent diabetic outpatients with and without retinopathy for plasma indices of hypothalamo-pituitary-adrenal (HPA) axis activity. Diabetic patients with moderate-to-severe retinopathy had significantly higher postdexamethasone plasma levels of adrenocorticotropic hormone than patients with minimal or no retinopathy. However, when duration of diabetes was taken into account this difference was no longer significant. These data suggest that dysregulation of the HPA axis and retinal microvascular complications found in diabetic patients may both be a function of duration of diabetes. |
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