Highly potent activity of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in animal models of Parkinson's disease |
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Authors: | Ardashov Oleg V Pavlova Alla V Il'ina Irina V Morozova Ekaterina A Korchagina Dina V Karpova Elena V Volcho Konstantin P Tolstikova Tat'yana G Salakhutdinov Nariman F |
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Affiliation: | Russian Academy of Sciences, Novosibirsk, Russian Federation. |
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Abstract: | (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown. |
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