结核病分子流行病学特征性研究

目的　运用结核病分子生物学手段,对DOTS策略实施效果进行监测和评价。方法 对肺结核病人培养阳性痰标本采用MIRU-VNTR分型法技术进行分子流行病学分析和其结核病人流行病学相关性的回顾性调查。结果 分子流行病学分析结果2004年成簇率为70%,其中山东基因型簇为22%,山东基因型簇比例较2002年下降了50%(P<0.005);流行病学相关率为32.5%。结论 结核病分子生物学研究结果可作为DOTS实施效果监测和评价的客观指标之一。

The study of molecular epidemiology under the quality control of DOTS strategy in tuberculosis

Objective To make use of Methods of molecular epidemiology to evaluate the comprehensive effect of tuberculosis control under the implementation of the quality control of DOTS strategy in tuberculosis. Methods Retrospective study was adopted to research the positive sample of tuberculosis patients by the molecular epidemiology, as well as to investigate patients clustered to look for the epidemiology link. Results During the period of a study of molecular epidemiology under the implementation of the quality control of DOTS strategy in tuberculosis, in terms of the MIRU-VNTR examination, the cluster rate was 70%,of which the Shandong cluster accounted for 22%, and the proportion was significantly decreased compared with it was in 2002(P<0.005); the epidemiological correlation rate was 32.5%. Conclusion The Results of the study of molecular epidemiology would be one of the Methods to evaluate the effectiveness as the Objective under the implementation of quality control of DOTS strategy in tuberculosis.