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Kinetoplast DNA from Trypanosoma vivax and T. congolense |
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| Authors: | P Borst F Fase-Fowler P J Weijers J D Barry L Tetley K Vickerman |
| Affiliation: | 1. The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;2. B.C.P. Jansen Institute, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands;3. Institute of Genetics, University of Glasgow, Church Street, Glasgow G11 5JS, U.K.;4. Department of Zoology, University of Glasgow, Glasgow G12 8QQ, U.K. |
| Abstract: | We have analysed kinetoplast DNA (kDNA) of the African trypanosomes Trypanosoma vivax and T. congolense. The maxi-circles from these organisms resemble those of T. brucei in size, but only to a limited extent in sequence as judged from restriction enzyme digests and DNA X DNA hybridization. The kDNA networks of T. vivax have three distinguishing features: they contain the highest maxi-circle concentration of any kDNA (at least twice that of T. brucei); they contain the smallest mini-circles (465 bp) yet found thus far and the width of the kDNA nucleoid in thin sections is correspondingly small (55 nm against 91 nm for T. brucei); they contain a substantial fraction of mini-circle dimers. |
| Keywords: | Kinetoplast DNA Maxi-circle Mini-circle |
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