羟丙基-β-环糊精对葛根素溶解性与角膜渗透性的影响

 目的研究羟丙基-β-环糊精(HPCD)对葛根素溶解性与角膜透过性的影响。方法采用了相溶解度法和离体角膜扩散实验。结果在不同浓度HPCD下,葛根素的相溶解曲线呈AL型;随着HPCD浓度的增大,葛根素的表观渗透系数减小。50 g·L^-1HPCD增溶的表观渗透系数分别是以150 g·L^-1HPCD和40 g·L^-1PVP增溶的3.12和2.86倍,但150 g·L^-1HPCD与40 g·L^-1PVP增溶的表观渗透系数相比没有显著性差异(P>0.05)。结论HPCD能增加葛根素的溶解度与提高其角膜透过性。

Effect of Hydroxypropyl Beta Cyclodextrin on Aqueous Solubility and Corneal Permeation of Puerarin

OBJECTIVE To investigate the effect of hydroxypropyl beta cyclodextrin(HPCD)on aqueous solubility and corneal permeation of puerarin.METHODS The solubility of puerarin with HPCD was investigated by phase-solubility method.The permeability of puerarin across isolated rabbits cornea was measured in vitro.RESULTS An A_L-type phase solubility curve was obtained.The apparent permeation coefficient of puerarin decreased as the concentration of HPCD increased.The apparent permeation coefficient at 50 g·L^-1HPCD 1evel was increased by 3.12 times as that at 150 g·L^-1HPCD 1evel,and 2.86 times as that at 40 g·L^-1PVP 1evel.There was no significant difference(P>0.05)between the apparent permeation coefficient at 150 g·L^-1HPCD 1evel and 40 g·L^-1PVP 1evel.CONCLUSION The solubilizing effect of HPCD on puerarin in aqueous solution is good.HPCD enhances the permeability of puerarin across isolated rabbits cornea.