57株嗜麦芽黄单胞菌下呼吸道感染相关性和耐药性分析

目的 分析57株嗜麦芽黄单胞菌下呼吸道感染的相间性和耐药性况,探讨嗜麦芽黄单胞菌引起下呼吸道感染的防治措施. 方法 对我院2001-2004年下呼吸道标本分离的57株嗜麦芽黄单胞菌,根据临床资料和药敏结果进行回顾性统计分析.细菌鉴定和药敏试验采用Micro Scan40/96全自动微生物鉴定仪. 结果 57株嗜麦芽黄单胞菌均来自ICU病房,其中93.0%来自呼吸内科ICU病房,7.0%来自颅脑外科ICU病房,90%以上为高龄慢支患者,嗜麦芽黄单胞菌好发于下呼吸道感染,且是使用高效广谱抗生素-泰能后而诱发.药敏结果呈示,对复方新诺明的敏感率为78.0%,头孢他啶的敏感率为45.0%,氨基糖苷类、喹诺酮类的敏感率＜20%,对亚胺培南,氨曲南天然耐药,对氨苄西林,头胞唑啉,头胞西丁,头胞噻吩,头胞呋肟均100%耐药. 结论 合理使用抗生素,缩短住院时间,增强机体免疫功能,均有利于减少嗜麦芽黄单胞菌引起的下呼吸道感染.

Analysis of antimicrobial resistance of 57 strains xanthomonas maltophilia from lower respiratory tract infection

Objective To investigate the antimicrobial resistance of 57 strain xanthomonas maltophilia from lower respiratory tract infection, so as to provide reference for reasonably selection of antibiotics. Methods 57 strains xanthomonas maltophilia from lower respiratory tract infection were isolated from patients in our hospital from year 2001 to 2004. The bacteria isolation and antimicrobial susceptibility were done by MicroScan 40/96. Retrospective analysis to the pathogens and their drug susceptibility characteristics was carried out. Results All 57 strains xanthomonas maltophilia were isolated from the intersive care units. 93% strains was isolated from respiratory department, and 7% strains was isolated from neurosurgical department. 90% persons infected with xanthomonas maltophilia from lower respiratory tract were old chronic bronchitis patients, and their infection with xanthomonas maltophilia happened after treatment with imipenem-cilastatin. Antimicrobial susceptibility showed that the antibiotics susceptible rate for sulfamethoxazole and ceftazidime was 78% and 45%, the rate of arninoglycosides and fluoroauinolones was below 20%. Xanthomonas maltophilia was completely resistant to inipenem, cefazolin, ampicillin, cefoxitin, cefalotin, and eefuroxime. Conclusions Infection with xanthomonas maltophilia can be prevented by selection of antibiotics, shorten hospital stay, enhanced body immunity.