草乌甲素脂质体的皮肤渗透性及抗炎镇痛作用

目的：考察草乌甲素脂质体的皮肤渗透性及抗炎镇痛效果。方法：采用正交设计详细考察了处方中各因素对透皮速率的影响；比较了脂质体与饱和水溶液的经皮渗透性；研究了脂质体对二甲苯所致急性炎症以及醋酸所致扭体反应的影响。结果：处方中磷脂、油酸、油酸钠对透皮速率有极显著性影响。脂质体可以明显加快草乌甲素的透皮吸收，缩短时滞。本品对炎症和疼痛均有明显的抑制作用，优于双氯芬酸钠乳胶剂对照组。结论：脂质体是草乌甲素透皮吸收的优良载体，有利于充分发挥药物的疗效。

Skin permeability and anti-inflammatory analgesic activities of bulleyaconitine A liposomes

AIM: To study the skin permeability and anti-inflammatory analgesic activities of bulleyaconitine A (BLA) liposomes. METHODS: Orthogonal test was employed to study the influence of liposomes components on the skin permeability. The permeability of BLA in liposomes and in saturated aqueous solution through rat skin was compared. The effect of BLA liposomes on the edema of mouse ear induced by dimethylbenzene and the writhing induced by acetic acid was also investigated. RESULTS: It was founded that lecithin, oleic acid and sodium oleate in liposomes were the major influence factors on the permeability of BLA. Liposomes could increase the flux of BLA and decrease the lag time greatly. The results of animal testes showed that BLA liposomes exhibited remarkable anti-inflammatory and analgesic activities. CONCLUSION: Liposomes is an effective carrier for the transdermal permeation of BLA.