Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat |
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| Authors: | Alexander Stiglick Mark E Llewellyn Harold Kalant |
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| Institution: | (1) Department of Pharmacology, University of Toronto, M5S 1A8 Toronto, Canada;(2) Addiction Research Foundation of Ontario, M5S 2S1 Toronto, Canada |
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| Abstract: | Chronic oral administration of cannabis extract to rats was examined for its residual effects on shuttle-box avoidance learning. In experiment 1 avoidance learning was assessed in rats that had been tested previosly on other behavioral tests. Chronic treatment (3 months) facilitated the learning of shuttle-box avoidance in cannabis-treated animals relative to vehicle controls. In experiment 2 very similar results were obtained in naive rats. These and other residual effects of chronic cannabis treatment are similar to the effects of hippocampal lesions. |
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| Keywords: | Chronic cannabis Shuttle-box avoidance |
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