氧化苦参碱对急性心肌梗死大鼠左室重构的干预作用

目的 观察不同剂量氧化苦参碱(OMT)对急性心肌梗死(AMI)大鼠心室重构的防治作用.方法 SD大鼠30只均分5组,除假手术组外,其他4组采用结扎冠状动脉左前降支的方法复制大鼠AMI模型后,其中3组分别用三种剂量OMT灌胃,8周后检测心指数、心肌重构指数、胶原含量并进行病理组织学检查,分析心室重构的程度.结果 冠脉结扎8周后,模型组大鼠心室重构各项指标与假手术组相比差异有统计学意义(P<0.01);OMT各组大鼠心室重构各项指标与模型组相比差异有统计学意义(P<0.05或P<0.01).结论 OMT能够有效延缓心脏结构的变异,抑制胶原沉积,对AMI后心室重构具有一定的预防作用.

Effects of oxymattine on left ventricular remodeling after acute myocardial infarction in rats

Objective To study the effects of oxymattine(OMT) on left ventricular remodeling after myocardial infarction(MI) in rats. Methods The MI models were established by ligation of the left anterior descending coronary artery in 24 SD rats, which were divided into model group and threeOMT intervention groups. The rats in OMT groups were given three different doses of OMT by direct gastric gabage for 8 weeks. Another 6 rats were taken as the sharm controls. Eight weeks later, the extent of myocardial remodeling with the myocardial remodeling index, collagen content and histopathological cganges were examined. Results Compared to the sham controls, significant changes in the myocardial remodeling were seen in model group (P<0. 01), which were significantly lower in OMT groups, especially with high dose OMT, than those in model group (P<0. 05 or P<0. 01).Conclusion Oxymatrine has some protective effects on the myocardial remodeling.