丝裂霉素C与羟基喜树碱预防膀胱癌复发的Meta分析

目的 比较丝裂霉素C(MMC)与羟基喜树碱(HCPT)膀胱灌注对膀胱癌复发的预防作用及治疗毒性.方法 筛选13个临床研究,包括416例进行MMC、595例进行HCPT膀胱灌注治疗的患者,进行系统分析.采用优势比(OR)及95%可信区间(95%CI)作为评价疗效及毒性差异的指标.统计软件为RevMan5.结果 Meta分析显示,HCPT膀胱灌注治疗预防肿瘤复发的疗效显著优于MMC(P<0.01).MMC组膀胱刺激症状、外周血白细胞数下降的发生率显著高于HCPT组(分别为P<0.01).结论 HCPT膀胱灌注预防膀胱癌复发作用优于MMC,且治疗毒性低于MMC.

A Meta-analysis on the prevention of recurrence of bladder cancer with mitomycin C and hydroxycamptothecin

Objective To compare the efficacy and toxicity of intravesical irrigation of mitomycin C(MMC) versus hydroxycamptothecin (HCPT) in preventing the recurrence of bladder cancer. Methods A total of 13 trials was eligible for the inclusion criteria,of which 416 patients were treated with MMC and 595 cases with HCPT. Odds ratio(OR) and its 95% confidence interval(CI) were used as the comparison parameter of efficacy and toxicity. The statistical analysis was performed using RevMan5 software. Results The results of Meta-analysis showed that HCPT was significantly superior to MMC in the prevention of tumor recurrence with less irritation sign of bladder and peripheral blood leucocyte descendent (P<0. 01). Conclusion The results of this meta-analysis suggest that intravesical irrigation of HCPT is better than that of MMC in preventing the recurrence of bladder cancer.