视黄醇结合蛋白与胱抑素C诊断早期2型糖尿病肾病的价值

目的 探讨视黄醇结合蛋白(RBP)与胱抑素C(Cys-C)水平对2型糖尿病肾病(T2DMN)的早期诊断价值.方法 对116例T2DMN患者(DN组)及38例健康者(C组)分别测定尿蛋白排泄率(UAER)、RBP、Cys-C、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)及尿微量白蛋白(mAlb)指标.Cys-C、RBP及UAER、mAlb的测定均采用免疫比浊分析法,NAG的测定采用化学酶法速率法.结果 DN组血RBP、尿RBP、Cys-C、NAG含量显著高于C组(P＜0.05),且各检测指标水平在不同的T2DMN临床分期间均有统计学差异(P＜0.05).T2DMN早期患者尿RBP阳性检出率高达56.84%.结论 尿RBP可以作为反映T2DM患者肾脏早期损伤灵敏、可靠的实验室指标;尿RBP与Cys-C同时检测可作为评价肾功能受损程度及部位的指标.

Diagnostic value of detecting retinal-binding protein and serous cystain C in early diabetic nephropathy

Objective To investigate the diagnostic value of detecting retinal-binding protein (RBP) and serous of cystatin C(Cys-C) in type 2 diabetic nephropathy(T2DMN).Methods The urinary albumin excretion rate (UAER),urinary and serum RBP,Cys-C,urinary N-acetyl-beta-D glucosaminidase (NAG),and urinary microalbumine (mAlb)were examined usingimmune nephelometry and reaction rate assay in 116 patients with T2DMN(group DN) and 38 healthy subjects (group C).Results Compared with group C,the blood RBP,urinary RBP,Cys-C,and NAG content were significantly higher in group DN (P＜0.05),which were significantly different among different clinical stages of diabetic nephropathy (P＜0.05).As high as 56.84% of urinary RBP positive rate was detected in T2DM patients with early diabetic nephropathy.Conclusion Urinary RBP detection may be taken as a sensitive and reliable marker for predicting the early renal injury in type 2 diabetes.Combined detection of urine RBP and Cys-C can be taken as the indicators for evaluating the extent and location of diabetic nephropathy.