2型糖尿病患者罗库溴铵的肌松效应

目的 观察2型糖尿病(T2DM)患者罗库溴铵的肌松效应.方法 60例择期手术全麻病人等分为基本资料相仿的T2DM(D组)和非糖尿病(C组)两组.全麻诱导时,快速静注罗库溴铵0.6 mg/kg,记录两组的肌松起效时间、临床时效、恢复时间和恢复指数.结果 与C组比较,D组肌松起效时间略长于对照组(P>0.05),临床时效、恢复时间和恢复指数均明显延长(P<0.05).结论 与非糖尿病患者比较,T2DM患者罗库溴铵的临床维持时间延长,恢复时间亦延迟.

Neuromuscular blockade of rocuronium in patients with type 2 diabetes mellitus

Objective To evaluate the neuromuscular blockade of rocuronium in patients with type 2 diabetes mellitus (T2DM). Methods Sixty patients undergoing selected surgery under total intravenous anesthesia were divided into two groups with 30 cases each. The patients in group D were with T2DM and those in group C without T2DM as the controls. During anesthesia inductions bolus of rocuronium 0. 6 mg/kg was injected and neuromuscular block criteria of onset time, the times for T1 recovered to 25% and 75%, and recovery index (RI) were monitored using train-of-four nerve stimulation. Results The onset time was not significantly different between tow groups (P>0. 05).The times for Tl recovered to 25% and 75%, and recovery index (RI) were significantly longer in group D than those in group C (P<0. 05). Conclusion Compared to the patients without diabetes mellitus,the clinical duration and recovery time of rocuronium are prolonged in patients with T2DM.