深低温保存同种肺动脉在复杂先天性心脏病治疗中的应用

目的 探讨深低温保存同种肺动脉治疗复杂先天性心脏病的疗效.方法 应用深低温保存同种肺动脉治疗复杂先天性心脏病25例.术前诊断:法洛四联症12例,肺动脉闭锁合并室间隔缺损6例,大动脉转位合并室间隔缺损和肺动脉瓣狭窄3例,右心窜双出口合并窒间隔缺损和肺动脉瓣狭窄2例,先天性主动脉瓣狭窄2例.结果 24例手术顺利完成,1例手术中死亡,术后院内死亡1例.其余23例均痊愈出院.随访6～60个月,无远期死亡,23例患者生活质量良好.复查超声心动图示植入的同种肺动脉无明显钙化、衰败.结论 深低温保存的同种肺动脉应用于复杂先天性心脏病矫治,具有良好的早、中期效果.

Clinical application of cryopreserved pulmonary homograft conduits in complex congenital heart diseases

Objective To study the clinical outcomes of cryopreserved pulmonary homograft conduits in the treatment of complex congenital heart disease(CHD). Methods Twenty-five patients with complex CHD received cryopreserved pulmonary homograft conduits transplantation. There were 12 cases with Tetralogy of Fallot, 6 cases with pulmonary atresia complicated by ventricular septal defect,and 3 cases with transposition of the great arteries complicated by ventricular septal defect and pulmonary stenosis , 2 cases with double outlet right ventricle complicated by ventricular septal defect and pulmonary stenosis, 2 cases with congenital aortic valve stenosis. Results Twenty-four patients completed the surgery. One case died of extracorporeal circulation after heart resuscitation during surgery and another one died of low cardiac output syndrome soon after surgery. The other 23 cases recovered and discharged from hospital. The patients were follow-up for 6 to 60 months, which showed good life quality without death case. Echocardiography showed no obvious calcification or degeneration in the implanted pulmonary homograft conduits. Conclusion Cryopreserved pulmonary homograft conduits have good early and midterm effectiveness in the treatment of complex congenital heart diseases.