埃索美拉唑为基础的三联一线治疗幽门螺杆菌的疗效

目的 观察埃索美拉哗联合左氧氟沙星和阿莫西林一线治疗幽门螺杆菌的疗效.方法 163例幽门螺杆菌阳性患者,随机分为3组,分别应用埃索美拉唑20mg每13 2次(A组),埃索美拉唑40 mg每13 2次(B组),埃索美拉唑40 mg每日1次(C组),3组均加用左氧氟沙星500 mg每日1次和阿莫西林1000 mg每日2次,疗程7 d.并且对幽门螺杆菌根除率分别按意愿治疗(ITT)分析和方案(PP)分析进行评估.结果 A、B、C组各治疗方案的根除率:ITT法为82.98%、87.10%、70.37%;PP法为86.67%、88.52%,73.08%.B组明显高于C组(P<0.05).结论 埃索美拉唑联合左氧氟沙星和阿莫西林一线治疗能显著提高幽门螺杆菌根除率.

Efficacy of esomeprazole-based triple therapy for Helicobacter pylori infection

Objective To observe the efficacy of esomeprazole-based triple therapy as the first-line treatment for Helicobacter pylori infectioa Methods A total of 163 patients with helicobacter pylori infection confirmed by rapid urease test and ~(13)C breath test was randomly divided into there groups. Esomeprazole 20 mg bid (group A) ,40 mg bid (group B) or 40 mg qd (group C) was used,which was combined with levofloxacin 500 mg qd and amoxicillin 1000 mg bid for 1 week. The eradication rates of Helicobacter pylori infection were tested with the methods of ITT and PP. Results The eradication rates for groups of A,B and C were 82. 98%,87. 10% and 70. 37% by ITT analysis, and were 86. 67% ,88. 52% and 73. 08% by PP analysis,respectively. The eradicaton rates of group B were higher than those of group C (P<0. 05). Conclusion Esomeprazole-based triple therapy as the first-line drugs for Helicobacter pylori infection can effectively improve the eradication rate.