| 上皮性钙黏附蛋白及弹力纤维在乳腺癌中表达及临床意义 |
| |
| 引用本文： | 王洁,程燕林,王晨亮.上皮性钙黏附蛋白及弹力纤维在乳腺癌中表达及临床意义[J].九江医学,2007,22(3):13-15. |
| |
| 作者姓名： | 王洁 程燕林 王晨亮 |
| |
| 作者单位： | 九江市第一人民医院病理科,江西九江,332000 |
| |
| 摘 要： | 目的:探讨上皮性钙黏附蛋白(E-cadherin,E-cad)与弹力纤维(elastic fiber,EF)在乳腺癌中的表达及意义。方法:用S-P免疫组化法及Weighert染色检测E-cad及EF在20例正常乳腺组织、30例乳腺良性肿瘤及150例乳腺癌中表达情况。结果:正常乳腺组织及乳腺良性肿瘤中E-cad高表达率明显高于乳腺癌,淋巴结转移数越多,E-cad高表达率呈减弱的趋势;随着淋巴结转移数越多,病理分级越高,EF明显增多,统计学有显著差异(p<0.01)。在乳腺癌中E-cad和EF的表达呈负相关。结论:E-cad和EF与乳腺癌淋巴结转移及预后密切相关,可作为判断乳腺癌转移潜能的及预后的有力参考指标。
|
| 关 键 词： | 上皮性钙黏附蛋白 乳腺癌 淋巴结转移 弹力纤维 预后 |
| 文章编号： | 1006-3838（2007）03-013-（03） |
| 收稿时间： | 2007-06-15 |
| 修稿时间： | 2007年6月15日 |
EXPRESSION AND CLINICAL SIGNIFICANCE OF E- CADHERIN AND ELASETIC FIBER IN BREST CANCER |
| |
| WANG Jie,CHENG Yanlin,WANG Chenliang.EXPRESSION AND CLINICAL SIGNIFICANCE OF E- CADHERIN AND ELASETIC FIBER IN BREST CANCER[J].Jiujiang Medical Journal,2007,22(3):13-15. |
| |
| Authors: | WANG Jie CHENG Yanlin WANG Chenliang |
| |
| Abstract: | OBJECTIVE:The purpose is to investigate the expression and significance of E-cadherin(E-cad) and elastic fiber(EF)in breast cancer.METHOD:Immunohistochemical S-P method and Weighert staining were used to detect E-cad and in 20 cases of normal breast tissues,30 cases of benign breast tumors and 150 cases of breast cancer.RESULTS:Higher expression of E-cad was detected in normal breast tissues and benign breast tumors than that in breast cancer.With increasing of metastasis of lymph nodes,E-cad expression decreased(p<0.01).With increasing of metastasis of lymph nodes and tumor's grading,EF expression increased.There was negative correlation between expression of E-cad and EF in breast cancer.CONCLUSION:The results suggest that expression of E-cad and EF are closely related to lymphatic metastasis and prognosis.It is a good indicator for assessing lymphatic metastasis and prognosis in the breast carcinoma. |
| |
| Keywords: | E-cadherin brest cancer metastasis of lymph nodes elastic fiber prognosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
