Genetic basis for conversion of rough-to-smooth colony morphology in Actinobacillus actinomycetemcomitans |
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| Authors: | Wang Ying Liu Amy Chen Casey |
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| Affiliation: | Division of Primary Oral Health Care, University of Southern California School of Dentistry, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA. |
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| Abstract: | The basis of the rough-to-smooth conversion of Actinobacillus actinomycetemcomitans was examined. Smooth variants often contained mutations at the flp promoter region. Replacing the mutated flp promoter with the wild-type promoter restored the rough phenotype. The expression level of the flp promoter was approximately 100-fold lower in smooth than in rough strains. Mutations of the flp promoter are a cause of the rough-to-smooth conversion. |
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