乳腺癌中BI-1基因与ER PR表达的关系及意义

目的：探讨乳腺癌BI-1基因与雌孕激素受体表达的关系及意义.方法：采用免疫组化S-P法检测48例乳腺癌及配对正常组织中BI-1的表达,并分析与ER、PR受体的关系.结果：乳腺癌及配对正常组织中BI-1表达阳性率分别为77.08%、18.75%,两组间相比有显著性差异（P＜0.05）.ER阴性组BI-1表达阳性率高于ER阳性组,阳性率分别为94.74%和65.52%差异有显著性（P＜0.05）;PR阳性和阴性组之间的表达差异无显著性（P＞0.05）：淋巴结转移组BI-1表达率高于未转移组（P＜0.05）.结论：BI-1与ER的联合检测是判断乳腺癌患者预后的重要指标.

Correlation Between Expression of the BI-1 Gene and Receptors for Estrogen and Progestogen and Its Significance in Breast Cancer

Objective:To investigate the correlation between the expression of the BI-1 gene and the receptors for estrogen and progestogen in breast cancer and its significance.Methods:Immunohistochemical methods were used to detect the expression of the BI-1 gene and the receptors for estrogen and progestogen in breast cancer.Results:The positive rates of expression of the BI-1 gene in breast cancer and matched normal tissues were 77.08% and 18.75%,respectively.The difference was statistically significant(P<0.05).The positive rate of expression of the BI-1 gene was higher in the group with no expression of estrogen receptor(94.74%)than that in the group with detectable expression of estrogen receptor(65.52%).There was no statistically significant difference in BI-1 expression between the progestogen receptor(PR)-positive and PR-negative groups(P>0.05).The positive rate of expression of the BI-1 gene was also higher in the group with lymph node metastasis than in the group without lymph node metastasis.The differences were statistically significant(P<0.05).Conclusion:Detecting expression of the BI-1 gene in combination with estrogen receptor is an important indicator for prognosis of breast cancer.