阿德福韦酯并薄芝糖肽治疗HBeAg阳性慢性乙型肝炎效果 |
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引用本文: | 马文洁,柳盛.阿德福韦酯并薄芝糖肽治疗HBeAg阳性慢性乙型肝炎效果[J].康复与疗养杂志,2011(2):133-134. |
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作者姓名: | 马文洁 柳盛 |
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作者单位: | 青岛市传染病医院,山东青岛266033 |
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摘 要: | 目的观察阿德福韦酯联合薄芝糖肽治疗HBeAg阳性慢性乙型肝炎的效果。方法 60例HBeAg阳性的慢性乙型肝炎病人随机分为治疗组和对照组。两组阿德福韦酯用量皆为10 mg,每天1次口服,共48周,治疗组同时加用薄芝糖肽4 mL,以50 g/L的葡萄糖注射液稀释后静脉滴注,每天1次,共12周。结果治疗组治疗12周后谷丙转氨酶复常率与对照组比较差异有显著性(χ2=4.29,P〈0.05)。治疗组各时间段HBV DNA阴转率显著高于对照组(χ2=4.34~5.08,P〈0.05)。结论阿德福韦酯联合薄芝糖肽治疗慢性乙型肝炎疗效肯定,值得推广应用。
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关 键 词: | 肝炎 乙型 慢性 阿德福韦酯 薄芝糖肽 治疗结果 |
EFFICACY OF ADEFOVIR DIPIVOXIL COMBINED WITH BOZHI GLYCOPEPTIDE FOR HBeAg-POSITIVE CHRONIC HEPATITIS B |
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Authors: | MA WEN-JIE LIU SHENG |
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Institution: | (Qingdao Infection Hospital,Qingdao 266033,China) |
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Abstract: | Objective To observe the clinical effects of adefovir dipivoxil combined with Bozhi glycopeptide for HBeAg-positive chronic hepatitis B. Methods Sixty patients were randomly divided into two groups,who were offered oral adefovir dipivoxil,10 mg once a day,for 48 weeks;for those in treatment group,Baozhi glycopeptide was added,4 mL,diluted in 50 g/L dextrose,intravenous drip,once a day,for 12 weeks. Results After 12 weeks of therapy,the recovery rate of ALT in the treatment group was significantly higher as compared with the control(χ2=4.29,P0.05),and the HBV DNA negative conversion rate was higher at each time point(χ2=4.34-5.08,P0.05). Conclusion Combo therapy with adefovir and Bozhi glycopeptide for HBeAg-positive chronic hepatitis B is effective and worth application.. |
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Keywords: | hepatitis B chronic adefovir dipivoxil Bozhi glycopeptide treatment outcome |
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