消脂饮防治大鼠高脂血症性脂肪肝的实验研究

目的研究消脂饮对大鼠实验性高脂血症性脂肪肝的防治作用。方法采用高脂乳剂建立大鼠高脂血症性脂肪肝模型，实验分为正常组、模型组、消脂饮高剂量组和低剂量组，以东宝肝泰为阳性组，以高、低剂量消脂饮和东宝肝泰进行干预，测定肝脂含量及肝中超歧物过氧化物酶（SOD）活性、丙二醛（MDA）含量和维生素E水平。结果用药各组肝中总胆固醇（TC）、低密度脂蛋白（LDL-C）、甘油三酯（TG）和肝MDA含量均明显降低；而肝SOD活性、维生素E水平和高密度脂蛋白（HDL-C）显著升高。结论消脂饮对大鼠高脂血症性脂肪肝具有预防和治疗作用，其机制可能是通过清除自由基，提高机体抗氧化能力。

Protective and therapeutic effect of Xiaozhi potion on fatty liver with hyperlipemia in rat model

Objective To determine the protective and therapeutic effect of Xiaozhi potion on fatty liver with hyperlipidemia. Methods Model of fatty liver with hyperlipidemia was created by feeding rats high fat emulsion. We divided the rats into a normal control group, a model group, a high dose group, a low dose group and a DongBaoGanTai group randomly. Each treatment group was intervened by its own medicine. The biochemical changes in the liver, and the SOD activity and the MDA content and Vit E level were tested in all groups. Results Compared with the model group, the TC, TG and LDL-C levels in rat livers were reduced markedly, the MDA content was much lowered, and the SOD activity and Vit E level were increased greatly. Conclusion Xiaozhi potion can effectively treat and prevent experimental fatty liver with hyperlipidemia in rats, and its mechanism may be associated with removing the free radicals and enhancing the capabilitv of anti oxidation.