Can fructose 1–6 diphosphate (FDP) be an additive to ECC during cardiac surgery? |
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| Authors: | Ali Belboul MD PhD Marcin Krotkjewski MD PhD Najib Al-Khaja MD PhD Olof Jonsson MD PhD Gudjon Haraldsson MD Donald Roberts MD PhD |
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| Institution: | (1) Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden;(2) Department of Medical Rehabilitation, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden;(3) Department of General Surgery, Sahlgrenska Sjukhuset, University of Gothenburg, Gothenburg, Sweden |
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| Abstract: | Extracorporeal circulation (ECC) is the basic support system for patients undergoing cardiac surgery, during which oxygen free radicals (OFR) are generated and involved in ischemic reperfusion injury. This study was done to investigate the protective function of fructose 1–6 diphosphate (FDP) with fresh human red blood cells (RBCs) as a model in vitro and presumably during ECC and cardiac surgery. RBCs were exposed to OFR and mechanical trauma, and then FDP was incubated to RBCs alone and then to RBCs plus OFR. Malondialdehyde (MDA) and red cell filtration rate (RFR) were measured. There was a significant decrease of MDA in RBCs exposed to FDP plus OFR (p<0.01,p<0.001) and an increase of RFR (p<0.05,p<0.001) when compared with RBCs alone or with OFR. A negative correlation was found between MDA and RFR. These results suggest that the protective action of FDP is promising as an additive during ECC in man so as to improve the blood cell rheology and the microcirculation in cardiac surgery with ECC. |
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