Percutaneous transvenous endomyocardial biopsy in human heart recipients. Experience with a new technique |
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Authors: | P K Caves E B Stinson M Billingham N E Shumway |
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Institution: | Division of Cardiovascular Surgery, Department of Surgery, and the Department of Pathology, Stanford University School of Medicine, Stanford, Calif., and the Department of Cardiac Surgery, University of Edinburgh, Edinburgh, Scotland |
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Abstract: | Sixty-seven cardiac biopsy procedures have been performed in 17 cardiac transplant recipients at Stanford University Medical Center. Six other patients were biopsied as part of their assessment prior to transplantation. Biopsies were performed percutaneously through a sheath inserted into the right internal jugular vein. Two instruments were used, a Konno-Sakakibara bioptome and a new catheter biopsy forceps of our own design. Biopsies of the endomyocardium sufficient for examination by light and electron microscopy were obtained on all but one occasion. There were no deaths and no serious complications.Serial biopsies performed in the first two months after transplantation were used to diagnose and aid the management of acute rejection episodes. Biopsies on long-term survivors permitted the recognition of late acute rejection episodes and provided a new assessment of the myocardium following cardiac transplantation.Percutaneous transvenous endomyocardial biopsy is simple and safe to perform and is an important new aid in the management of patients following cardiac transplantation. |
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Keywords: | Address reprint requests to Dr Stinson Department of Surgery Stanford University School of Medicine Stanford Calif 94305 |
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