Bmi-1基因在不同类型上皮性卵巢癌组织中的表达及临床意义

目的 探讨Bmi-1基因表达与不同类型上皮性卵巢癌恶性生物学行为的相关性.方法 采用免疫组化学SABC法检测10例浆液性囊腺癌、8例粘液性囊腺癌、6例宫内膜样癌,28例良性卵巢肿瘤和30例正常卵巢组织中Bmi-1基因的表达情况,并对其表达与患者年龄、组织学类型和临床分期之间的关系进行统计学分析.结果 （1） Bmi-1基因在浆液性癌中的阳性率是60.00％,在粘液性癌中的阳性率是62.50％,在恶性宫内膜样癌中的阳性率是50.00％,均显著高于良性卵巢上皮性肿瘤组织（7.14％）和正常卵巢组织（6.67％）,具有统计学意义（P＜0.05）;但在卵巢上皮性癌各组间组织学差异无统计学意义（P＞0.05）; （2） 24例卵巢上皮性癌中,Bmi-1基因在Ⅲ期患者组织中的阳性表达率（100％）显著高于Ⅰ～Ⅱ期患者组织（41.48％）,其阳性表达随国际妇产科联盟（FIGO 2000年）临床分期增高而增强,具有统计学意义（P＜0.05）,但其表达与卵巢上皮性癌患者的年龄差异无统计学意义（P＞0.05）.结论 Bmi-1基因与上皮性卵巢癌的发生、发展、进展中起重要作用.

Bmi-1 Expression in Different Types of Epithelial Ovarian Cancer Tissues and Its Clinical Significance

Objective The aim was to investigate the correlation of Bmi-1 gene expression with the malignant behavior of different types of epithelial ovarian cancer.Methods Immunohistochemical stains SABC method was used to detect the expression of Bmi-1 in epithelial ovarian cancer tissues,including 10 cases of serous adenocarcinoma,8 cases of mucinous adenocarcinoma,6 cases of endometrioid carcinoma,28 cases of benign ovarian tumor and 30 cases of normal ovarian tissue.And the relationship of the expression with age of patients,histological type and clinical stage were statistically analyzed.Results （1） The positive rate of Bmi-1 gene in serous adenocarcinoma,mucinous adenocarcinoma and endometrioid carcinoma was 60.00％,62.50％ and 50.00％,respectively.All rates were significantly higher than those in benign epithelial ovarian tumor （7.14％）and normal ovarian tissue （6.67％）,with statistical significance （P ＜ 0.05）,but there was no statistical difference among the ovarian epithelial carcinoma histological groups （P ＞ 0.05） （2） In 24 cases of epithelial ovarian cancer,the positive expression rate of Bmi-1 （100％） in the tissue of stage Ⅲ patients was significantly higher than that in the cancer tissue of stage Ⅰ-Ⅱ （41.48％）.And the expression was enhanced with the increased clinical stage of International Federation of Gynecology and Obstetrics （FIGO 2000）,with statistical significance （P ＜ 0.05）,but the expression of Bmi-1 was no difference in the age of epithelial ovarian cancer patients （P ＞0.05） Conclusion Bmi-1 gene plays an important role in the occurrence,development and progress of epithelial ovarian cancer.