Psychotic episode secondary to gonadotrophins

Objective

To report a case of a substance-induced psychotic disorder secondary to ovulation induction therapy with gonadotrophins.

Method

Case report.

Results

We report a case of a psychotic episode secondary to gonadotrophins therapy. The acute episode was treated with antipsychotic (Aripiprazole). After 2 years the patient remains free of psychotic symptoms.

Conclusion

There have been several reports correlating low levels of estrogen with psychotic symptoms, leading to studies evaluating the possible effect of this hormone as an antipsychotic. In this case, we report psychotic symptoms with high levels of estradiol, which is contrary to that theory.