Autoradiographic studies of protein turnover in motoneurons of IDPN-treated rats |
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Authors: | S M Chou R A Klein |
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Institution: | (1) Department of Pathology, West Virginia University, School of Medicine, 26506 Morgantown, West Virginia, USA;(2) Department of Neurology, West Virginia University, School of Medicine, Morgantown, West Virginia, USA |
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Abstract: | Summary Autoradiography was performed in order to envisage the turnover of H3-leucin labeled protein in the perikarya of spinal motoneurons and in the axonal balloons formed after repeated administrations of IDPN ( -![beta](/content/p32v7805g1027h23/xxlarge946.gif) -iminodiproprionitrile) in rats.These results suggested that (1) there was no significant, if any,in situ protein synthesis within the axon balloons, (2) the protein turnover was not appreciably altered in the perikarya of the control and IDPN-intoxicated rats, and (3) the labeled protein collected in the axon balloons seemed to be transported from the perikarya to which they were linked with short axonal segments (30 in average length).Supported in part by U.S. NIH Institutional Research Grant (and Neurology Foundation). |
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Keywords: | - gif" alt="beta" align="MIDDLE" BORDER="0">-![beta](/content/p32v7805g1027h23/xxlarge946</a> <a href=) gif" alt="beta" align="MIDDLE" BORDER="0"> -Iminodipropionitrile (IDPN)" target="_blank">gif" alt="prime" align="BASELINE" BORDER="0">-Iminodipropionitrile (IDPN) Axonal Balloons Protein Turnover Autoradiography H3-Leucine Spinal Motoneurons |
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