首页 | 本学科首页   官方微博 | 高级检索  
     


Applications of accelerator MS in pediatric drug evaluation
Authors:Lt Vuong  Ab Blood  Js Vogel  Me Anderson  B Goldstein
Affiliation:Vitalea Science, Inc., 2121 Second Street, Suite B101, Davis, CA 95618, USA.
Abstract:Accelerator MS (AMS) provides a novel method for obtaining and analyzing pharmacokinetics and pharmacodynamics in children. This paper reviews the scientific and ethical rationale for AMS in pediatric trials, the regulatory framework and general considerations with some specific examples of pediatric clinical trials using AMS. Microdosing in the context of this article refers to studies using a negligible amount (nanocuries) of (14)C as tracer, and AMS as a quantitative technique. The technology is by no means a panacea for the deficiency in pediatric clinical research; however, it lessens the challenges and provides the most quantitative tool for pediatric pharmacology studies.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号