A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation |
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Authors: | Yasuhiro Takikawa Yuki Yasumi Akihiro Sato Ryujin Endo Kazuyuki Suzuki Yasuki Mori Hidetoshi Akasaka Yasuhiro Miura Takashi Sawai Hiroaki Okamoto |
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Institution: | First Department of Internal Medicine, Iwate Medical University, Morioka, Japan. |
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Abstract: | A 65-year-old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction. |
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Keywords: | cholestasis drug hypersensitivity eosinophilia eruption hepatitis E hypersensitivity syndrome |
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