| 山药多糖对小鼠CCL_4肝损伤的保护作用 |
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| 引用本文： | 孙设宗,唐微,张红梅,官守涛,赵杰,刘兴林.山药多糖对小鼠CCL_4肝损伤的保护作用[J].郧阳医学院学报,2008,27(6). |
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| 作者姓名： | 孙设宗 唐微 张红梅 官守涛 赵杰 刘兴林 |
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| 作者单位： | [1]郧阳医学院生化与免疫学实验室,湖北十堰442000 [2]郧阳医学院实验动物中心,湖北十堰442000 |
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| 摘 要： | 目的:探讨山药多糖对小鼠CCL4肝损伤的保护作用及可能作用机制。方法:昆明种小鼠50只随机分空白对照组;模型组;高、中、低山药多糖组,每天分别给予50 mg/kg、100 mg/kg、200 mg/kg剂量的山药多糖灌胃,连续8 d,末次灌胃2 h,空白对照组腹腔注射调和油溶液,其余各组腹腔注射0.15%CCL4调和油溶液,24 h眼球取血测定血清中ALT、AST活性和MDA含量。取肝脏,称重计算肝体指数;制备肝匀浆,按试剂盒要求测定MDA、SOD、GSH的含量。结果:山药多糖可减轻实验性肝损伤所致炎性反应,降低肝体指数,降低血清中ALT、AST活性(P(0.05)和MDA的含量(P(0.01);提高肝细胞中GSH的含量(P(0.01)及降低MDA的含量(P(0.01)。结论:山药多糖对CCL4造成的实验性肝损伤有保护作用,其机制可能与山药多糖抗氧化作用有关。
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| 关 键 词： | 山药多糖 肝损伤 自由基 |
Protective Effect of Yam Polysaccharide on CCL_4-induced Liver Injury in Mice |
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| SUN She-zhong,TANG Wei,ZHANG Hong-mei,GUAN Shou-tao,Zhao Jie,LIU Xing-lin.Protective Effect of Yam Polysaccharide on CCL_4-induced Liver Injury in Mice[J].Journal of Yunyang Medical College,2008,27(6). |
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| Authors: | SUN She-zhong TANG Wei ZHANG Hong-mei GUAN Shou-tao Zhao Jie LIU Xing-lin |
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| Institution: | SUN She-zhong1,TANG Wei1,ZHANG Hong-mei1,GUAN Shou-tao1,Zhao Jie1,LIU Xing-lin2(1Biochemistry , Immunology Laboratory,2Experimental Animal Center,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To explore the protective effect of Yam polysaccharide on CCL4-induced liver injury.Methods Kunming mice were randomly divided into control group,pathological model group and low,medium,high dosage of Yam polysaccharide groups.Three Yam polysaccharide subgroups were given Yam for 8 days by the body weight dosage 50 mg/kg,100mg/kg,200mg/kg,respectively.The control group was intra-peritoneally injected blend oil solution,and the other groups was intra-peritoneally given 0.15% CCL4 mixed with blend o... |
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| Keywords: | Yam polysaccharide Liver injury Free radicals |
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