抑郁症患者短期治疗前后述情障碍的研究

目的 探讨抑郁症患者短期治疗后述情障碍的变化及治疗后述情障碍的影响因素.方法 采用多伦多述情量表(TAS)中文版、Beck抑郁自评量表(BDI),对80例抑郁症患者于治疗前后(新型抗抑郁剂3周以上)进行评定,并与95名健康志愿者(对照组)比较.结果 (1)治疗前抑郁症组TAS与BDI评分均显著高于对照组(P<0.01).重度抑郁组TAS因子I、II及总分均高于轻、中度抑郁组(P<0.05);中度抑郁组仅TAS因子II得分高于轻度抑郁组(P<0.05).(2)治疗后抑郁症患者TAS总分(52.73±9.41)分]、因子I(17.88±5.61)分]、因子II(13.08±3.42)分]、BDI总分(8.74±7.27)分]较治疗前均降低分别为 (58.45±10.17)分、(21.56±5.45)分、(16.64±3.35)分、(23.86±9.27)分;P<0.01].治疗后抑郁症组TAS因子I(17.88±5.61)分]、因子III(21.78±4.01)分]、总分(52.73±9.41)分]仍高于对照组分别为(15.90±4.26)分、(19.09±3.03)分、(48.04±8.79)分;P<0.01].(3)治疗后抑郁总分、服务满意度、治疗信心、对疾病的了解依次进入TAS总分的回归方程.结论 抑郁症存在明显的述情障碍,抑郁总分等是述情障碍的重要影响因素,短期治疗可降低述情障碍的严重程度.述情障碍可能既是一种人格特质,又是对抑郁的一种反应.

A study on the alexithymia in major depressive patients prior and post a short-term treatment

ObjectiveTo explore the alexithymia change and its influencing factors in major depressive patients prior and post a short-term treatment. Methods80 major depressive patients were assessed with the Chinese version of the twenty-item Toronto Alexithymia Scale (TAS) and Beck Depression Inventory (BDI) prior and post a short-term treatment (with a new type antidepressant over 3 weeks),and 95 healthy people were involved as controls. ResultsBefore treatment, major depressive patients showed significantly higher scores in BDI and TAS (P<0.01). Compared with mild and midrange depressive patients, major ones showed higher scores in TAS factor I, II and total scores(P<0.05), and midrange depressive patients had higher scores in TAS factor II than mild ones(P<0.05).(2)Compared with themselves, the major depressive patients made improvements in TAS total score (52.73±9.41) vs (58.45±10.17)], factor I(17.88±5.61) vs (21.56±5.45)], factor II (13.08±3.42) vs (16.64±3.35)] and BDI total score (8.74±7.27) vs (23.86±9.27)] post a short-term treatment(P<0.01). Compared with controls, the major depressive patients still had higher scores in TAS factor I(17.88±5.61) vs (15.90±4.26), P<0.01],factor III(21.78±4.01) vs (19.09±3.03), P<0.01] and total scores(52.73±9.41) vs (48.04±8.79), P<0.01].(3)The factor of total score of BDI, satisfactory degree for service, confidence for treatment and the degree to learn about depression entered the TAS total score regression equation in turn in post-treatment. ConclusionsMajor depressive patients suffered from significant alexithymia. The total score of BDI et al were responsible for alexithymia in major depressive patients. Patients could got improvement in alexithymia during short-term treatment. Alexithymia not only may be a stable personality trait but also a state-dependent phenomenon.