紫杉醇联合顺铂双周和三周疗法治疗晚期非小细胞肺癌

 目的比较和评价紫杉醇联合顺铂双周和三周方案治疗晚期非小细胞肺癌(NSCLC)的近期疗效和毒性。方法经病理和细胞学证实的60例ⅢⅣ期NSCLC患者随机分为两组。双周疗法组(n=30例)紫杉醇80mg/m2,顺铂40mg/m2ivgttd1,8,第21天重复;三周疗法(n=30例)紫杉醇140mg/m2,顺铂60mg/m2ivgttd1,第21天重复。测定给药后3,12,24h的血药浓度,并评价经化疗2周期后的疗效和毒副反应。结果双周疗法和三周疗法的有效率分别为40.0%和33.3%,差异无统计学意义,但双周疗法的毒副反应发生率较低。结论紫杉醇联合顺铂双周方案治疗晚期NSCLC较三周疗法更为安全有效,患者易于接受,适用于临床,值得增加病例数做深入研究。

Double and Three-week Regime of Paclitaxel Combined with Cisplatin in Treatment of Advanced Non-small Cell Lung Cancer

Objective 　To evaluate the efficacy and toxicity of paclitaxel combined with cisplatin in the t reatment of advanced non2small cell lung cancer (NSCLC) by double and three2week regime. Methods 　 Sixty patient s with locally advanced ( stage Ⅲ) or metastatic ( stage Ⅳ) NSCLC were enrolled into the study and divided to two group s. Double week regime ( n = 30) : paclitaxel 80 mg/ m2 , cisplatin 40 mg/ m2 ivgtt d1 ,8 ,and it was repeated at d 21. Three2week regime ( n = 30) : paclitaxel 140 mg/ m2 , cisplatin 60 mg/ m2 ivgtt d1 and it was repeated at d 21. A HPLC method was established for the determination of pa2 clitaxel at 3 ,12 , 24 h af ter administ ration , and evaluate the efficacy and toxicity af ter two chemotherapy cycles. Results 　The overall response rate of double week regime and three2week regime were 40. 0 % and 36. 7 % , respectively , there was no statistic difference , but the main toxicities of double week regime were lower. Conclusion 　Double week regime is a better method for the t reatment of advanced NSCLC , it could increase patient s for further study.