Complete nucleotide sequence and genomic organization of a primate calicivirus, Pan-1 |
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| Authors: | J. E. Rinehart-Kim W.-M. Zhong X. Jiang A. W. Smith D. O. Matson |
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| Affiliation: | (1) Center for Pediatric Research, Children’s Hospital of The King’s Daughters and Eastern Virginia Medical School, Norfolk, Virginia, U.S.A., NF;(2) Laboratory of Calicivirus Studies, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, U.S.A., US |
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| Abstract: | Summary. The primate calicivirus, Pan-1, was originally isolated from several primate species. It displayed typical calicivirus morphology by electron micro-scopy. We determined the genomic sequence of Pan-1 by cDNA cloning and direct RNA sequencing. Pan-1 shares a similar genomic organization and a high degree of sequence identity with feline caliciviruses. The Pan-1 genome contains 8 304 nucleotides, plus a poly-A tail, and is longer than any other calicivirus strains with a completely known sequence. The extra sequences of Pan-1 include a unique 424-nucleotide sequence at the 5′ end of ORF1, additional amino acids at the N-terminus of the capsid, and a longer 3′ UTR. Received March 20, 1998 Accepted July 22 |
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