| 阿尔采末病的实验性治疗研究进展 |
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| 引用本文： | 乐卫东,张晓洁.阿尔采末病的实验性治疗研究进展[J].中国新药与临床杂志,2006,25(9):661-667. |
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| 作者姓名： | 乐卫东 张晓洁 |
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| 作者单位： | 1. 上海交通大学医学院附属瑞金医院神经病学研究所,中国科学院上海生命科学研究院、上海交通大学医学院健康科学研究所,上海,200025;贝勒医学院神经科,得克萨斯州休斯顿,77030,美国
2. 上海交通大学医学院附属瑞金医院神经病学研究所,中国科学院上海生命科学研究院、上海交通大学医学院健康科学研究所,上海,200025 |
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| 摘 要： | 随着人们对阿尔采末病(AD)发病机制的深入研究,未来AD的治疗也将从传统的抗乙酰胆碱酶疗法转变为针对淀粉样斑块形成,淀粉样多肽介导的毒性作用及神经原纤维缠结形成的多发病机制的研究。这篇综述将对包括以分泌酶为基础的治疗、免疫治疗、抗神经原纤维缠结的治疗以及传统中医治疗在内的各种新的实验性疗法做一个大体的论述。
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| 关 键 词： | 阿尔采末病 淀粉样前体蛋白分泌酶 神经原纤维缠结 免疫治疗 基因治疗 实验性治疗 传统中医治疗 |
| 文章编号： | 1007-7669（2006）09-0660-07 |
| 收稿时间： | 2006-04-29 |
| 修稿时间： | 2006-04-292006-07-27 |
Advances in experimental therapy for Alzheimer's disease |
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| LE Wei-dong,ZHANG Xiao-jie.Advances in experimental therapy for Alzheimer''''s disease[J].Chinese Journal of New Drugs and Clinical Remedies,2006,25(9):661-667. |
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| Authors: | LE Wei-dong ZHANG Xiao-jie |
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| Institution: | 1.Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine; lnsititute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, SHANGHAI 200025, China; 2.Department of Neurology, Baylor College of Medicine, Houston TEXAS 77030, USA |
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| Abstract: | With the advancement in the understanding of the pathogenesis of Alzherimer's disease (AD),the trend of therapy for AD has shifted from conventional anti-acetylcholinesterase treatment to multiple mechanism-based therapies aiming at the decreases of amyloid plaques formation,amyloid peptides-mediated toxicity and neurofibrillary tangles generation.This review has covered updated experimental studies and clinical trials with the focus on seeretases-based therapy,immunotherapy,anti-neurofibrillary tangles therapy and the traditional Chinese medicine therapy.These new therapies show great potential in delaying disease progression and neuroprotection in experimental studies or clinical trials,which may highlight the possibility that AD could be cured in the future. |
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| Keywords: | Alzheimer disease amyloid precursor protein secretase neurofibrillary tangles immunotherapy gene therapy experimental therapy traditional Chinese medicine therapy |
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